Pseudomonas aeruginosa PAO1, PA3891 (opuCA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3891
Name
opuCA
Replicon chromosome
Genomic location 4356876 - 4358039 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
CommentBroad-spectrum QAC-transporter activated by hyperosmolarity
CommentBroad-spectrum QAC-transporter activated by hyperosmolarity

Cross-References

RefSeq NP_252580.1
GI 15599086
Affymetrix PA3891_at
Entrez 878813
GenBank AAG07278.1
INSDC AAG07278.1
NCBI Locus Tag PA3891
protein_id(GenBank) gb|AAG07278.1|AE004806_5|gnl|PseudoCAP|PA3891
TIGR NTL03PA03891
UniParc UPI00000C5B5F
UniProtKB Acc Q9HXC2
UniProtKB ID Q9HXC2_PSEAE
UniRef100 UniRef100_A0A0C7D159
UniRef50 UniRef50_Q8ZPK4
UniRef90 UniRef90_W0YVU2

Product

Feature Type CDS
Coding Frame 1
Product Name
OpuC ABC transporter, ATP-binding protein, OpuCA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -4.66
Kyte-Doolittle Hydrophobicity Value -0.267
Molecular Weight (kDa) 43.3
Isoelectric Point (pI) 5.77

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001779 (493 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3891
Search term: opuCA

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40]
E-value: 4.9e-23
Percent Identity: 29.5
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40]
E-value: 4.9e-23
Percent Identity: 29.5
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40]
E-value: 4.9e-23
Percent Identity: 29.5

References

Characterization of the osmoprotectant transporter OpuC from Pseudomonas syringae and demonstration that cystathionine-beta-synthase domains are required for its osmoregulatory function.
Chen C, Beattie GA
J Bacteriol 2007 Oct;189(19):6901-12
PubMed ID: 17660277