Pseudomonas aeruginosa PAO1, PA3933 (betT3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3933
Name
betT3
Synonym: betT3
Replicon chromosome
Genomic location 4408924 - 4410885 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentLow affinity, choline-specific importer functions at both high and low osmolarity
CommentLow affinity, choline-specific importer functions at both high and low osmolarity

Cross-References

RefSeq NP_252622.1
GI 15599128
Affymetrix PA3933_at
Entrez 879067
GenBank AAG07320.1
INSDC AAG07320.1
NCBI Locus Tag PA3933
protein_id(GenBank) gb|AAG07320.1|AE004811_3|gnl|PseudoCAP|PA3933
TIGR NTL03PA03933
UniParc UPI00000C5B82
UniProtKB Acc Q9HX83
UniProtKB ID Q9HX83_PSEAE
UniRef100 UniRef100_S0ISN9
UniRef50 UniRef50_Q4KK36
UniRef90 UniRef90_B7VAI9

Product

Feature Type CDS
Coding Frame 1
Product Name
BetT3
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 3.47
Kyte-Doolittle Hydrophobicity Value 0.392
Molecular Weight (kDa) 72.2
Isoelectric Point (pI) 7.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 255 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001742 (829 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3933
Search term: betT3
Search term: BetT3

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Molecular cloning, physical mapping and expression of the bet genes governing the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
Andresen PA, Kaasen I, Styrvold OB, Boulnois G, Strøm AR
J Gen Microbiol 1988 Jun;134(6):1737-46
PubMed ID: 3065456
Roles of three transporters, CbcXWV, BetT1, and BetT3, in Pseudomonas aeruginosa choline uptake for catabolism.
Malek AA, Chen C, Wargo MJ, Beattie GA, Hogan DA
J Bacteriol 2011 Jun;193(12):3033-41
PubMed ID: 21478341