Pseudomonas aeruginosa PAO1, PA3974 (ladS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3974
Name
ladS
Replicon chromosome
Genomic location 4453289 - 4455676 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252663.1
GI 15599169
Affymetrix PA3974_at
Entrez 878890
GenBank AAG07361.1
INSDC AAG07361.1
NCBI Locus Tag PA3974
protein_id(GenBank) gb|AAG07361.1|AE004815_5|gnl|PseudoCAP|PA3974
TIGR NTL03PA03974
UniParc UPI00000C5BAA
UniProtKB Acc Q9HX42
UniProtKB ID Q9HX42_PSEAE
UniRef100 UniRef100_Q9HX42
UniRef50 UniRef50_W0YUZ0
UniRef90 UniRef90_W0YUZ0

Product

Feature Type CDS
Coding Frame 1
Product Name
Lost Adherence Sensor, LadS
Product Name Confidence: Class 1
Synonyms Lost Adherence Sensor, LadS
Evidence for Translation
Charge (pH 7) -1.84
Kyte-Doolittle Hydrophobicity Value 0.118
Molecular Weight (kDa) 88.2
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002178 (1344 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3974
Search term: ladS

Human Homologs

References

Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes.
Ventre I, Goodman AL, Vallet-Gely I, Vasseur P, Soscia C, Molin S, Bleves S, Lazdunski A, Lory S, Filloux A
Proc Natl Acad Sci U S A 2006 Jan 3;103(1):171-6
PubMed ID: 16373506
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins.
Aricó B, Miller JF, Roy C, Stibitz S, Monack D, Falkow S, Gross R, Rappuoli R
Proc Natl Acad Sci U S A 1989 Sep;86(17):6671-5
PubMed ID: 2549542
The arcB gene of Escherichia coli encodes a sensor-regulator protein for anaerobic repression of the arc modulon.
Iuchi S, Matsuda Z, Fujiwara T, Lin EC
Mol Microbiol 1990 May;4(5):715-27
PubMed ID: 2201868
Structural and genetic analysis of the bvg locus in Bordetella species.
Aricò B, Scarlato V, Monack DM, Falkow S, Rappuoli R
Mol Microbiol 1991 Oct;5(10):2481-91
PubMed ID: 1791760