Pseudomonas aeruginosa PAO1, PA4057 (nrdR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4057
Name
nrdR
Synonym: nrdR
Synonym: ybaD
Replicon chromosome
Genomic location 4538039 - 4538503 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252746.1
GI 15599252
Affymetrix PA4057_at
DNASU PaCD00007775
Entrez 879080
GenBank AAG07444.1
INSDC AAG07444.1
NCBI Locus Tag PA4057
protein_id(GenBank) gb|AAG07444.1|AE004822_4|gnl|PseudoCAP|PA4057
TIGR NTL03PA04057
UniParc UPI00001398F7
UniProtKB Acc Q9HWX1
UniProtKB ID NRDR_PSEAE
UniRef100 UniRef100_B7V7Q1
UniRef50 UniRef50_Q4K592
UniRef90 UniRef90_B7V7Q1

Product

Feature Type CDS
Coding Frame 1
Product Name
NrdR
Product Name Confidence: Class 1
Synonyms NrdR
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.84
Kyte-Doolittle Hydrophobicity Value -0.628
Molecular Weight (kDa) 17.9
Isoelectric Point (pI) 7.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 455 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001627 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4057
Search term: nrdR
Search term: NrdR

Human Homologs

References

Two proteins mediate class II ribonucleotide reductase activity in Pseudomonas aeruginosa: expression and transcriptional analysis of the aerobic enzymes.
Torrents E, Poplawski A, Sjöberg BM
J Biol Chem 2005 Apr 29;280(17):16571-8
PubMed ID: 15722359
Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: cross-regulation and physiological role in response to oxygen limitation.
Borovok I, Gorovitz B, Yanku M, Schreiber R, Gust B, Chater K, Aharonowitz Y, Cohen G
Mol Microbiol 2004 Nov;54(4):1022-35
PubMed ID: 15522084
Function of the Pseudomonas aeruginosa NrdR Transcription Factor: Global Transcriptomic Analysis and Its Role on Ribonucleotide Reductase Gene Expression.
Crespo A, Pedraz L, Torrents E
PLoS One 2015;10(4):e0123571
PubMed ID: 25909779