Pseudomonas aeruginosa PAO1, PA4123 (hpcC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4123
Name
hpcC
Synonym: hpaE
Replicon chromosome
Genomic location 4611013 - 4612473 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252812.1
GI 15599318
Affymetrix PA4123_hpcC_at
Entrez 880100
GenBank AAG07510.1
INSDC AAG07510.1
NCBI Locus Tag PA4123
protein_id(GenBank) gb|AAG07510.1|AE004828_11|gnl|PseudoCAP|PA4123
TIGR NTL03PA04123
UniParc UPI00000C5C20
UniProtKB Acc Q9HWQ8
UniProtKB ID Q9HWQ8_PSEAE
UniRef100 UniRef100_W0YWK3
UniRef50 UniRef50_Q5SJP9
UniRef90 UniRef90_Q4KBA6

Product

Feature Type CDS
Coding Frame 1
Product Name
5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -4.28
Kyte-Doolittle Hydrophobicity Value -0.098
Molecular Weight (kDa) 53.0
Isoelectric Point (pI) 6.38

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 603 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001576 (596 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4123
Search term: hpcC

Human Homologs

Ensembl 110, assembly GRCh38.p14
aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471]
E-value: 4.2e-112
Percent Identity: 40.9

References

Kinetic properties of 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Escherichia coli.
Alonso JM, Garrido-Pertierra A
Biochimie 1986 May;68(5):731-7
PubMed ID: 3089331
Sequence of the hpcC and hpcG genes of the meta-fission homoprotocatechuic acid pathway of Escherichia coli C: nearly 40% amino-acid identity with the analogous enzymes of the catechol pathway.
Roper DI, Stringfellow JM, Cooper RA
Gene 1995 Apr 14;156(1):47-51
PubMed ID: 7737515
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
Prieto MA, Díaz E, García JL
J Bacteriol 1996 Jan;178(1):111-20
PubMed ID: 8550403