Pseudomonas aeruginosa PAO1, PA4306 (flp)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4306
Name
flp
Replicon chromosome
Genomic location 4830964 - 4831182 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252996.1
GI 15599502
Affymetrix PA4306_at
DNASU PaCD00007867
Entrez 881572
GenBank AAG07694.1
INSDC AAG07694.1
NCBI Locus Tag PA4306
protein_id(GenBank) gb|AAG07694.1|AE004847_1|gnl|PseudoCAP|PA4306
TIGR NTL03PA04307
UniParc UPI00000C5CAB
UniProtKB Acc Q9HW94
UniProtKB ID Q9HW94_PSEAE
UniRef100 UniRef100_Q9HW94
UniRef50 UniRef50_Q9HW94
UniRef90 UniRef90_Q9HW94

Product

Feature Type CDS
Coding Frame 1
Product Name
Type IVb pilin, Flp
Product Name Confidence: Class 1
Synonyms Type IVb pilin, Flp
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.05
Kyte-Doolittle Hydrophobicity Value 0.771
Molecular Weight (kDa) 7.3
Isoelectric Point (pI) 4.46

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 8 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003907 (312 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4306
Search term: flp

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
FppA, a novel Pseudomonas aeruginosa prepilin peptidase involved in assembly of type IVb pili.
de Bentzmann S, Aurouze M, Ball G, Filloux A
J Bacteriol 2006 Jul;188(13):4851-60
PubMed ID: 16788194