Pseudomonas aeruginosa PAO1, PA4363 (iciA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA4363
Name
iciA
Synonym: lysR
Replicon chromosome
Genomic location 4891345 - 4892247 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253053.1
GI 15599559
Affymetrix PA4363_iciA_at
Entrez 881413
GenBank AAG07751.1
INSDC AAG07751.1
NCBI Locus Tag PA4363
protein_id(GenBank) gb|AAG07751.1|AE004852_4|gnl|PseudoCAP|PA4363
TIGR NTL03PA04364
UniParc UPI000012D167
UniProtKB Acc Q9HW38
UniProtKB ID ARGP_PSEAE
UniRef100 UniRef100_Q02H78
UniRef50 UniRef50_Q02H78
UniRef90 UniRef90_Q02H78

Product

Feature Type CDS
Coding Frame 1
Product Name
inhibitor of chromosome initiation IciA
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -1.19
Kyte-Doolittle Hydrophobicity Value 0.112
Molecular Weight (kDa) 32.5
Isoelectric Point (pI) 6.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 207 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003956 (572 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4363
Search term: iciA

Transposon Insertions in PAO1

Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 51134
Genomic Position 4892014
Position in ORF 670(903)
Reference 14617778
Type ISphoA/hah insertion site
Mutant ID UWGC: 33822
Genomic Position 4891764
Position in ORF 420(903)
Reference 14617778

Transposon Insertions in Orthologs

References

iciA, an Escherichia coli gene encoding a specific inhibitor of chromosomal initiation of replication in vitro.
Thony B, Hwang DS, Fradkin L, Kornberg A.
Proc Natl Acad Sci U S A. 1991 May 15;88(10):4066-70.
PubMed ID: 2034653
Molecular characterization of lysR-lysXE, gcdR-gcdHG and amaR-amaAB operons for lysine export and catabolism: a comprehensive lysine catabolic network in Pseudomonas aeruginosa PAO1.
Madhuri Indurthi S(1), Chou HT(1), Lu CD(2).
Microbiology. 2016 May;162(5):876-88.
PubMed ID: 26967762