Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4375
|
Name |
mexW
|
Replicon | chromosome |
Genomic location | 4904647 - 4907703 (+ strand) |
Transposon Mutants | 8 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 3 transposon mutants in orthologs |
RefSeq | NP_253065.1 |
GI | 15599571 |
Affymetrix | PA4375_at |
Entrez | 881377 |
GenBank | AAG07763.1 |
INSDC | AAG07763.1 |
NCBI Locus Tag | PA4375 |
protein_id(GenBank) | gb|AAG07763.1|AE004853_6|gnl|PseudoCAP|PA4375 |
TIGR | NTL03PA04376 |
UniParc | UPI00000C5CEC |
UniProtKB Acc | Q9HW27 |
UniProtKB ID | Q9HW27_PSEAE |
UniRef100 | UniRef100_W0YXB9 |
UniRef50 | UniRef50_G8Q6V3 |
UniRef90 | UniRef90_W0YXB9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexW
|
Synonyms |
probable RND efflux transporter |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -17.64 |
Kyte-Doolittle Hydrophobicity Value | 0.361 |
Molecular Weight (kDa) | 110.5 |
Isoelectric Point (pI) | 4.96 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexW | MexW is the RND-type membrane protein of the efflux complex MexVW-OprM. [PMID:12951344] | ARO:3003031 | protein homolog model | Perfect | 1906.3 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001500 (799 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4375
Search term: mexW
|
A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa.
Li Y, Mima T, Komori Y, Morita Y, Kuroda T, Mizushima T, Tsuchiya T
J Antimicrob Chemother 2003 Oct;52(4):572-5
PubMed ID: 12951344
|