Pseudomonas aeruginosa PAO1, PA4381 (colR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4381
Name
colR
Replicon chromosome
Genomic location 4912141 - 4912824 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253071.1
GI 15599577
Affymetrix PA4381_at
DNASU PaCD00007895
Entrez 881364
GenBank AAG07769.1
INSDC AAG07769.1
NCBI Locus Tag PA4381
protein_id(GenBank) gb|AAG07769.1|AE004854_5|gnl|PseudoCAP|PA4381
TIGR NTL03PA04382
UniParc UPI00000C5CF1
UniProtKB Acc Q9HW21
UniProtKB ID Q9HW21_PSEAE
UniRef100 UniRef100_W0Z0E9
UniRef50 UniRef50_Q5P3W8
UniRef90 UniRef90_W0Z0E9

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator ColR
Product Name Confidence: Class 1
Synonyms probable two-component response regulator
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.41
Kyte-Doolittle Hydrophobicity Value -0.161
Molecular Weight (kDa) 25.2
Isoelectric Point (pI) 5.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003971 (530 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4381
Search term: colR

Human Homologs

References

A two-component system plays an important role in the root-colonizing ability of Pseudomonas fluorescens strain WCS365.
Dekkers LC, Bloemendaal CJ, de Weger LA, Wijffelman CA, Spaink HP, Lugtenberg BJ
Mol Plant Microbe Interact 1998 Jan;11(1):45-56
PubMed ID: 9425686
Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems.
Gutu AD, Sgambati N, Strasbourger P, Brannon MK, Jacobs MA, Haugen E, Kaul RK, Johansen HK, Høiby N, Moskowitz SM
Antimicrob Agents Chemother 2013 May;57(5):2204-15
PubMed ID: 23459479