Pseudomonas aeruginosa PAO1, PA4393 (ampG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4393
Name
ampG
Synonym: ampG
Replicon chromosome
Genomic location 4922407 - 4924191 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253083.1
GI 15599589
Affymetrix PA4393_at
Entrez 881279
GenBank AAG07781.1
INSDC AAG07781.1
NCBI Locus Tag PA4393
protein_id(GenBank) gb|AAG07781.1|AE004855_3|gnl|PseudoCAP|PA4393
TIGR NTL03PA04394
UniParc UPI00000D4210
UniProtKB Acc G3XCT7
UniProtKB ID G3XCT7_PSEAE
UniRef100 UniRef100_G3XCT7
UniRef50 UniRef50_A4VP88
UniRef90 UniRef90_G3XCT7

Product

Feature Type CDS
Coding Frame 1
Product Name
AmpG
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 10.24
Kyte-Doolittle Hydrophobicity Value 0.767
Molecular Weight (kDa) 64.6
Isoelectric Point (pI) 9.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 244 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003983 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4393
Search term: ampG
Search term: AmpG

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
AmpG, a signal transducer in chromosomal beta-lactamase induction.
Lindquist S, Weston-Hafer K, Schmidt H, Pul C, Korfmann G, Erickson J, Sanders C, Martin HH, Normark S
Mol Microbiol 1993 Aug;9(4):703-15
PubMed ID: 8231804
The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers.
Schmidt H, Korfmann G, Barth H, Martin HH
Microbiology (Reading) 1995 May;141 ( Pt 5):1085-1092
PubMed ID: 7773404
The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Science 1997 Sep 5;277(5331):1453-62
PubMed ID: 9278503
ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression.
Zhang Y, Bao Q, Gagnon LA, Huletsky A, Oliver A, Jin S, Langaee T
Antimicrob. Agents Chemother. 2010 Nov;54(11):4772-9
PubMed ID: 20713660
Pseudomonas aeruginosa β-lactamase induction requires two permeases, AmpG and AmpP.
Kong KF, Aguila A, Schneper L, Mathee K
BMC Microbiol. 2010 Dec;10
PubMed ID: 21192796