Pseudomonas aeruginosa PAO1, PA4457

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4457
Name
Synonym: yrbH
Synonym: kdsD
Synonym: kpsF
Replicon chromosome
Genomic location 4989305 - 4990285 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentBLAST: PA4457 vs NCBI, E = 3e-130 for arabinose 5-phosphate isomerase Pseudomonas fluorescens Pf-5. Modeling evidence, since necessary for KDO synthesis.

Cross-References

RefSeq NP_253147.1
GI 15599653
Affymetrix PA4457_at
DNASU PaCD00007933
Entrez 881001
GenBank AAG07845.1
INSDC AAG07845.1
NCBI Locus Tag PA4457
protein_id(GenBank) gb|AAG07845.1|AE004860_1|gnl|PseudoCAP|PA4457
TIGR NTL03PA04458
UniParc UPI00000C5D1C
UniProtKB Acc Q9HVW0
UniProtKB ID KDSD_PSEAE
UniRef100 UniRef100_Q9HVW0
UniRef50 UniRef50_Q9HVW0
UniRef90 UniRef90_Q9HVW0

Product

Feature Type CDS
Coding Frame 1
Product Name
arabinose-5-phosphate isomerase KdsD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.89
Kyte-Doolittle Hydrophobicity Value 0.278
Molecular Weight (kDa) 34.2
Isoelectric Point (pI) 5.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 437 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004046 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4457

Human Homologs

References

The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Science 1997 Sep 5;277(5331):1453-62
PubMed ID: 9278503
Reduced polysialic acid capsule expression in Escherichia coli K1 mutants with chromosomal defects in kpsF.
Cieslewicz M, Vimr E
Mol Microbiol 1997 Oct;26(2):237-49
PubMed ID: 9383150
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P
J Bacteriol 2002 Jan;184(2):363-9
PubMed ID: 11751812