Pseudomonas aeruginosa PAO1, PA4498 (mdpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4498
Name
mdpA
Replicon chromosome
Genomic location 5034860 - 5036077 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253188.1
GI 15599694
Affymetrix PA4498_at
Entrez 881083
GenBank AAG07886.1
INSDC AAG07886.1
NCBI Locus Tag PA4498
protein_id(GenBank) gb|AAG07886.1|AE004863_6|gnl|PseudoCAP|PA4498
TIGR NTL03PA04499
UniParc UPI00000C5D3A
UniProtKB Acc Q9HVS3
UniProtKB ID Q9HVS3_PSEAE
UniRef100 UniRef100_W0YXS6
UniRef50 UniRef50_Q485R4
UniRef90 UniRef90_B7V038

Product

Feature Type CDS
Coding Frame 1
Product Name
metallo-dipeptidase aeruginosa, MdpA
Product Name Confidence: Class 1
Synonyms probable metallopeptidase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.80
Kyte-Doolittle Hydrophobicity Value -0.203
Molecular Weight (kDa) 44.1
Isoelectric Point (pI) 6.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 663 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004086 (318 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4498
Search term: mdpA

Human Homologs

Ensembl 110, assembly GRCh38.p14
X-prolyl aminopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:28052]
E-value: 4.4e-14
Percent Identity: 29.8

References

Genetic analysis of genes involved in dipeptide metabolism and cytotoxicity in Pseudomonas aeruginosa PAO1.
Kiely PD, O'Callaghan J, Abbas A, O'Gara F
Microbiology (Reading) 2008 Aug;154(Pt 8):2209-2218
PubMed ID: 18667554