Pseudomonas aeruginosa PAO1, PA4505 (dppD)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 5044054 - 5045028 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_253195.1
GI 15599701
Affymetrix PA4505_at
Entrez 881158
GenBank AAG07893.1
INSDC AAG07893.1
NCBI Locus Tag PA4505
protein_id(GenBank) gb|AAG07893.1|AE004864_5|gnl|PseudoCAP|PA4505
UniParc UPI00000C5D41
UniProtKB Acc Q9HVR6
UniRef100 UniRef100_U9IKI5
UniRef50 UniRef50_Q4KIC6
UniRef90 UniRef90_A0A069PYH4


Feature Type CDS
Coding Frame 1
Product Name
dipeptide ABC transporter ATP-binding protein DppD
Product Name Confidence: Class 1
Evidence for Translation
Detected using LC-MS/MS (35.43 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.01
Kyte-Doolittle Hydrophobicity Value 0.045
Molecular Weight (kDa) 35.4
Isoelectric Point (pI) 6.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004092 (540 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA4505
Search term: dppD

Human Homologs

Ensembl 86, assembly GRCh38.p7
ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40]
E-value: 1.1e-15
Percent Identity: 32.3

Transposon Insertions in PAO1

Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 41254
Genomic Position 5044203
Position in ORF 150(975)
Reference 14617778

Transposon Insertions in Orthologs

Type MAR2xT7 transposon (wild type background) insertion site
Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag PA14_58470
Mutant ID PA14NR: 28820
Genomic Position 5207954
Position in ORF 313(975)
Reference 16477005


Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS.
Proteomics. 2011 Aug;11(16):3424-9.
PubMed ID: 21751344
High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.
Pletzer D(1), Lafon C(2), Braun Y(1), Köhler T(3), Page MG(4), Mourez M(2), Weingart H(1).
PLoS One. 2014 Oct 22;9(10):e111311.
PubMed ID: 25338022