Pseudomonas aeruginosa PAO1, PA4540

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4540
Name
Synonym: lepB
Replicon chromosome
Genomic location 5080757 - 5082394 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 8 transposon mutants in orthologs

Cross-References

RefSeq NP_253230.1
GI 15599736
Affymetrix PA4540_at
Entrez 877788
GenBank AAG07928.1
INSDC AAG07928.1
NCBI Locus Tag PA4540
protein_id(GenBank) gb|AAG07928.1|AE004867_14|gnl|PseudoCAP|PA4540
TIGR NTL03PA04541
UniParc UPI00000C5D5B
UniProtKB Acc Q9HVN7
UniProtKB ID Q9HVN7_PSEAE
UniRef100 UniRef100_Q9HVN7
UniRef50 UniRef50_Q9HVN7
UniRef90 UniRef90_Q9HVN7

Product

Feature Type CDS
Coding Frame 1
Product Name
hypothetical protein
Product Name Confidence: Class 4
Synonyms LepB
Evidence for Translation
Charge (pH 7) 3.64
Kyte-Doolittle Hydrophobicity Value -0.480
Molecular Weight (kDa) 60.3
Isoelectric Point (pI) 8.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Outer Membrane Class 2
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2MHJ PROTEIN TRANSPORT 11/25/13 Solution structure of TpsB4 N-terminal POTRA domain from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA NOT SOLUTION NMR 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 153 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000040 (1642 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4540

References

A gene cluster involved in the utilization of both free heme and heme:hemopexin by Haemophilus influenzae type b.
Cope LD, Yogev R, Muller-Eberhard U, Hansen EJ
J. Bacteriol. 1995 May;177(10):2644-53
PubMed ID: 7751272
A novel secreted protease from Pseudomonas aeruginosa activates NF-kappaB through protease-activated receptors.
Kida Y, Higashimoto Y, Inoue H, Shimizu T, Kuwano K
Cell. Microbiol. 2008 Jul;10(7):1491-504
PubMed ID: 18331590