Pseudomonas aeruginosa PAO1, PA4551 (pilV)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4551
Name
pilV
Replicon chromosome
Genomic location 5098709 - 5099266 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
CommentAlgR positively regulates the fimU-pilVWXY1Y2E operon

Cross-References

RefSeq NP_253241.1
GI 15599747
Affymetrix PA4551_pilV_at
DNASU PaCD00007971
Entrez 879607
GenBank AAG07939.1
INSDC AAG07939.1
NCBI Locus Tag PA4551
protein_id(GenBank) gb|AAG07939.1|AE004869_3|gnl|PseudoCAP|PA4551
TIGR NTL03PA04552
UniParc UPI00000D4278
UniProtKB Acc G3XD84
UniProtKB ID G3XD84_PSEAE
UniRef100 UniRef100_W0YZ79
UniRef50 UniRef50_W0YZ79
UniRef90 UniRef90_W0YZ79

Product

Feature Type CDS
Coding Frame 1
Product Name
type 4 fimbrial biogenesis protein PilV
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 3.28
Kyte-Doolittle Hydrophobicity Value -0.143
Molecular Weight (kDa) 20.1
Isoelectric Point (pI) 8.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0082
Category Type IVa pili
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 44 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005156 (464 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4551
Search term: pilV

Human Homologs

References

Identification of a gene, pilV, required for type 4 fimbrial biogenesis in Pseudomonas aeruginosa, whose product possesses a pre-pilin-like leader sequence.
Alm RA, Mattick JS
Mol Microbiol 1995 May;16(3):485-96
PubMed ID: 7565109
Pseudomonas aeruginosa AlgR regulates type IV pilus biosynthesis by activating transcription of the fimU-pilVWXY1Y2E operon.
Belete B, Lu H, Wozniak DJ
J Bacteriol 2008 Mar;190(6):2023-30
PubMed ID: 18178737