Pseudomonas aeruginosa PAO1, PA4596 (esrC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4596
Name
esrC
Replicon chromosome
Genomic location 5149064 - 5149582 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
CommentInducible by an envelope stress such as biocides

Cross-References

RefSeq NP_253286.1
GI 15599792
Affymetrix PA4596_at
DNASU PaCD00007991
Entrez 881060
GenBank AAG07984.1
INSDC AAG07984.1
NCBI Locus Tag PA4596
protein_id(GenBank) gb|AAG07984.1|AE004873_6|gnl|PseudoCAP|PA4596
TIGR NTL03PA04597
UniParc UPI00000C5D7F
UniProtKB Acc Q9HVJ0
UniProtKB ID Q9HVJ0_PSEAE
UniRef100 UniRef100_U8MYC6
UniRef50 UniRef50_U6ZWI5
UniRef90 UniRef90_V6AM72

Product

Feature Type CDS
Coding Frame 1
Product Name
EsrC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.41
Kyte-Doolittle Hydrophobicity Value -0.315
Molecular Weight (kDa) 19.1
Isoelectric Point (pI) 9.92

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 15 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004254 (298 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4596
Search term: esrC
Search term: EsrC

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
EsrC, an envelope stress-regulated repressor of the mexCD-oprJ multidrug efflux operon in Pseudomonas aeruginosa.
Purssell A, Fruci M, Mikalauskas A, Gilmour C, Poole K
Environ Microbiol 2015 Jan;17(1):186-98
PubMed ID: 25143244