Pseudomonas aeruginosa PAO1, PA4615 (fprB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4615
Name
fprB
Replicon chromosome
Genomic location 5172771 - 5173547 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253305.1
GI 15599811
Affymetrix PA4615_at
Entrez 881128
GenBank AAG08003.1
INSDC AAG08003.1
NCBI Locus Tag PA4615
protein_id(GenBank) gb|AAG08003.1|AE004875_9|gnl|PseudoCAP|PA4615
TIGR NTL03PA04616
UniParc UPI00000C5D8B
UniProtKB Acc Q9HVH6
UniProtKB ID Q9HVH6_PSEAE
UniRef100 UniRef100_A0A072ZP46
UniRef50 UniRef50_Q4K5Q5
UniRef90 UniRef90_A0A022P8U1

Product

Feature Type CDS
Coding Frame 1
Product Name
FprB
Product Name Confidence: Class 1
Synonyms probable oxidoreductase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.09
Kyte-Doolittle Hydrophobicity Value -0.177
Molecular Weight (kDa) 29.4
Isoelectric Point (pI) 5.22

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 284 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004269 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4615
Search term: fprB
Search term: FprB

Human Homologs

References

Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein.
Bianchi V, Reichard P, Eliasson R, Pontis E, Krook M, Jörnvall H, Haggård-Ljungquist E
J Bacteriol 1993 Mar;175(6):1590-5
PubMed ID: 8449868
Pseudomonas aeruginosa IscR-Regulated Ferredoxin NADP(+) Reductase Gene (fprB) Functions in Iron-Sulfur Cluster Biogenesis and Multiple Stress Response.
Romsang A, Duang-Nkern J, Wirathorn W, Vattanaviboon P, Mongkolsuk S
PLoS One 2015;10(7):e0134374
PubMed ID: 26230408