Pseudomonas aeruginosa PAO1, PA4625 (cdrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4625
Name
cdrA
Replicon chromosome
Genomic location 5186411 - 5192875 (- strand)
Transposon Mutants 11 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253315.1
GI 15599821
Affymetrix PA4625_at
Entrez 881174
GenBank AAG08013.1
INSDC AAG08013.1
NCBI Locus Tag PA4625
protein_id(GenBank) gb|AAG08013.1|AE004876_8|gnl|PseudoCAP|PA4625
TIGR NTL03PA04626
UniParc UPI00000C5D95
UniProtKB Acc Q9HVG6
UniProtKB ID Q9HVG6_PSEAE
UniRef100 UniRef100_Q9HVG6
UniRef50 UniRef50_Q9HVG6
UniRef90 UniRef90_Q9HVG6

Product

Feature Type CDS
Coding Frame 1
Product Name
cyclic diguanylate-regulated TPS partner A, CdrA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -25.77
Kyte-Doolittle Hydrophobicity Value -0.090
Molecular Weight (kDa) 219.8
Isoelectric Point (pI) 4.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Extracellular Class 1
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 124 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004278 (285 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4625
Search term: cdrA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix.
Borlee BR, Goldman AD, Murakami K, Samudrala R, Wozniak DJ, Parsek MR
Mol Microbiol 2010 Feb;75(4):827-42
PubMed ID: 20088866