Pseudomonas aeruginosa PAO1, PA4664 (prmC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA4664
Name
prmC
Synonym: hemK
Replicon chromosome
Genomic location 5231653 - 5232483 (- strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253353.1
GI 15599859
Affymetrix PA4664_hemK_at
Entrez 881353
GenBank AAG08051.1
INSDC AAG08051.1
NCBI Locus Tag PA4664
protein_id(GenBank) gb|AAG08051.1|AE004880_7|gnl|PseudoCAP|PA4664
TIGR NTL03PA04665
UniParc UPI00000C5DB7
UniProtKB Acc Q9HVC8
UniProtKB ID PRMC_PSEAE
UniRef100 UniRef100_Q9HVC8
UniRef50 UniRef50_Q9HVC8
UniRef90 UniRef90_Q9HVC8

Product

Feature Type CDS
Coding Frame 1
Product Name
S-adenosylmethionine-dependent methyltransferase, PrmC
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -7.37
Kyte-Doolittle Hydrophobicity Value -0.168
Molecular Weight (kDa) 30.5
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 609 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004314 (560 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4664
Search term: prmC

References

Cloning and sequencing of a previously unidentified gene that is involved in the biosynthesis of heme in Escherichia coli.
Nakayashiki T, Nishimura K, Inokuchi H
Gene 1995 Feb;153(1):67-70
PubMed ID: 7883187
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.
Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T
DNA Res. 1996 Jun;3(3):137-55
PubMed ID: 8905232
Functional analysis of the hemK gene product involvement in protoporphyrinogen oxidase activity in yeast.
Le Guen L, Santos R, Camadro JM
FEMS Microbiol. Lett. 1999 Apr;173(1):175-82
PubMed ID: 10220893
The peptide chain release factor methyltransferase PrmC is essential for pathogenicity and environmental adaptation of Pseudomonas aeruginosa PA14.
Pustelny C, Brouwer S, Müsken M, Bielecka A, Dötsch A, Nimtz M, Häussler S
Environ. Microbiol. 2013 Feb;15(2):597-609
PubMed ID: 23278968