Pseudomonas aeruginosa PAO1, PA4672

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA4672
Name
Synonym: pth
Replicon chromosome
Genomic location 5240122 - 5240706 (+ strand)

Cross-References

RefSeq NP_253361.1
GI 15599867
Affymetrix PA4672_at
Entrez 881396
GenBank AAG08059.1
INSDC AAG08059.1
NCBI Locus Tag PA4672
protein_id(GenBank) gb|AAG08059.1|AE004881_2|gnl|PseudoCAP|PA4672
TIGR NTL03PA04673
UniParc UPI000013292B
UniProtKB Acc Q9HVC3
UniProtKB ID PTH_PSEAE
UniRef100 UniRef100_B7V0L8
UniRef50 UniRef50_Q8Y2E3
UniRef90 UniRef90_B7V0L8

Product

Feature Type CDS
Coding Frame 1
Product Name
peptidyl-tRNA hydrolase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.39
Kyte-Doolittle Hydrophobicity Value -0.114
Molecular Weight (kDa) 20.8
Isoelectric Point (pI) 9.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4QBK HYDROLASE 05/08/14 Crystal structure of the complex of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with amino acyl-tRNA analogue at 1.77 Angstrom resolution PSEUDOMONAS AERUGINOSA 1.77 X-RAY DIFFRACTION 100.0
4ERX HYDROLASE 04/21/12 Crystal structure of the complex of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with diethylene glycol at 2.5 Angstrom resolution PSEUDOMONAS AERUGINOSA 2.5 X-RAY DIFFRACTION 100.0
4FYJ HYDROLASE 07/04/12 Crystal Structure of P. aeruginosa peptidyl-tRNA hydrolase PSEUDOMONAS AERUGINOSA 1.77 X-RAY DIFFRACTION 100.0
4JC4 HYDROLASE 02/21/13 Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa at 2.25 angstrom resolution PSEUDOMONAS AERUGINOSA 2.25 X-RAY DIFFRACTION 100.0
4DHW HYDROLASE 01/30/12 Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with Adipic acid at 2.4 Angstrom resolution PSEUDOMONAS AERUGINOSA 2.43 X-RAY DIFFRACTION 100.0
4DJJ HYDROLASE 02/02/12 Crystal structure of the complex of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with Pimelic acid at 2.9 Angstrom resolution PSEUDOMONAS AERUGINOSA 2.94 X-RAY DIFFRACTION 100.0
4QD3 HYDROLASE 05/13/14 Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with 5-azacytidine at 1.89 Angstrom resolution PSEUDOMONAS AERUGINOSA 1.89 X-RAY DIFFRACTION 100.0
4FNO HYDROLASE 06/20/12 Crystal structure of peptidyl t-RNA hydrolase from Pseudomonas aeruginosa at 2.2 Angstrom resolution PSEUDOMONAS AERUGINOSA 2.25 X-RAY DIFFRACTION 100.0
4QAJ HYDROLASE 05/05/14 Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa at 1.5 Angstrom resolution PSEUDOMONAS AERUGINOSA 1.5 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 589 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004322 (562 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4672

References

Crystallization and preliminary X-ray analysis of Escherichia coli peptidyl-tRNA hydrolase.
Schmitt E, Fromant M, Plateau P, Mechulam Y, Blanquet S
Proteins 1997 May;28(1):135-6
PubMed ID: 9144799
Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase.
Schmitt E, Mechulam Y, Fromant M, Plateau P, Blanquet S
EMBO J. 1997 Aug;16(15):4760-9
PubMed ID: 9303320