Pseudomonas aeruginosa PAO1, PA4705 (phuW)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4705
Name
phuW
Synonym: phuW
Replicon chromosome
Genomic location 5284370 - 5285257 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253393.1
GI 15599899
Affymetrix PA4705_at
DNASU PaCD00008042
Entrez 881531
GenBank AAG08091.1
INSDC AAG08091.1
NCBI Locus Tag PA4705
protein_id(GenBank) gb|AAG08091.1|AE004884_9|gnl|PseudoCAP|PA4705
TIGR NTL03PA04706
UniParc UPI00000C5DD4
UniProtKB Acc Q9HV92
UniProtKB ID Q9HV92_PSEAE
UniRef100 UniRef100_Q9HV92
UniRef50 UniRef50_Q4K5Z8
UniRef90 UniRef90_Q02FW8

Product

Feature Type CDS
Coding Frame 1
Product Name
PhuW
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 2.32
Kyte-Doolittle Hydrophobicity Value -0.409
Molecular Weight (kDa) 32.9
Isoelectric Point (pI) 7.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 83 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004354 (440 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4705
Search term: phuW
Search term: PhuW

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes.
Ochsner UA, Vasil ML
Proc Natl Acad Sci U S A 1996 Apr 30;93(9):4409-14
PubMed ID: 8633080
Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa.
Ochsner UA, Johnson Z, Vasil ML
Microbiology (Reading) 2000 Jan;146 ( Pt 1):185-198
PubMed ID: 10658665