Pseudomonas aeruginosa PAO1, PA4706 (phuV)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4706
Name
phuV
Synonym: phuV
Replicon chromosome
Genomic location 5285268 - 5286035 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253394.1
GI 15599900
Affymetrix PA4706_at
Entrez 881536
GenBank AAG08092.1
INSDC AAG08092.1
NCBI Locus Tag PA4706
protein_id(GenBank) gb|AAG08092.1|AE004884_10|gnl|PseudoCAP|PA4706
TIGR NTL03PA04707
UniParc UPI00000D4299
UniProtKB Acc O68877
UniProtKB ID HMUV_PSEAE
UniRef100 UniRef100_Q02FW7
UniRef50 UniRef50_Q02FW7
UniRef90 UniRef90_Q02FW7

Product

Feature Type CDS
Coding Frame 1
Product Name
PhuV
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.65
Kyte-Doolittle Hydrophobicity Value 0.017
Molecular Weight (kDa) 27.5
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001543 (890 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4706
Search term: phuV
Search term: PhuV

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55]
E-value: 1.4e-13
Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55]
E-value: 1.4e-13
Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55]
E-value: 1.4e-13
Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55]
E-value: 1.4e-13
Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55]
E-value: 1.4e-13
Percent Identity: 29.9
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55]
E-value: 1.4e-13
Percent Identity: 29.9

References

Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes.
Ochsner UA, Vasil ML
Proc Natl Acad Sci U S A 1996 Apr 30;93(9):4409-14
PubMed ID: 8633080
Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa.
Ochsner UA, Johnson Z, Vasil ML
Microbiology (Reading) 2000 Jan;146 ( Pt 1):185-198
PubMed ID: 10658665