Pseudomonas aeruginosa PAO1, PA4764 (fur)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4764
Name
fur
Replicon chromosome
Genomic location 5351675 - 5352079 (- strand)

Cross-References

RefSeq NP_253452.1
GI 15599958
Affymetrix PA4764_fur_at
DNASU PaCD00008066
Entrez 881780
GenBank AAG08150.1
INSDC AAG08150.1
NCBI Locus Tag PA4764
protein_id(GenBank) gb|AAG08150.1|AE004890_3|gnl|PseudoCAP|PA4764
TIGR NTL03PA04765
UniParc UPI000012AD84
UniProtKB Acc Q03456
UniProtKB ID FUR_PSEAE
UniRef100 UniRef100_Q03456
UniRef50 UniRef50_Q03456
UniRef90 UniRef90_Q03456

Product

Feature Type CDS
Coding Frame 1
Product Name
ferric uptake regulation protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.35
Kyte-Doolittle Hydrophobicity Value -0.262
Molecular Weight (kDa) 15.2
Isoelectric Point (pI) 5.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6H1C TRANSCRIPTION 07/11/18 Structure of Ferric uptake regulator from Pseudomonas aeruginosa with manganese. Pseudomonas aeruginosa PAO1 2.34 X-RAY DIFFRACTION 98.5
1MZB GENE REGULATION 10/07/02 Ferric uptake regulator Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database Victors : 4257
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Mus musculus
Notes
Reference 7642283

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 526 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004408 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4764
Search term: fur

Human Homologs

References

Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters.
Ochsner UA, Vasil AI, Vasil ML
J Bacteriol 1995 Dec;177(24):7194-201
PubMed ID: 8522528
Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene.
Prince RW, Cox CD, Vasil ML
J Bacteriol 1993 May;175(9):2589-98
PubMed ID: 8478325