Pseudomonas aeruginosa PAO1, PA4765 (omlA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4765
Name
omlA
Synonym: oprX
Replicon chromosome
Genomic location 5352177 - 5352707 (+ strand)

Cross-References

RefSeq NP_253453.1
GI 15599959
Affymetrix PA4765_omlA_at
Entrez 881781
GenBank AAG08151.1
INSDC AAG08151.1
NCBI Locus Tag PA4765
protein_id(GenBank) gb|AAG08151.1|AE004890_4|gnl|PseudoCAP|PA4765
TIGR NTL03PA04766
UniParc UPI0000130CE3
UniProtKB Acc O68562
UniProtKB ID BAME_PSEAE
UniRef100 UniRef100_O68562
UniRef50 UniRef50_O68562
UniRef90 UniRef90_O68562

Product

Feature Type CDS
Coding Frame 1
Product Name
Outer membrane lipoprotein OmlA precursor
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected using LC-MS/MS (19.39 kDa, PMID:21751344)
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.83
Kyte-Doolittle Hydrophobicity Value -0.517
Molecular Weight (kDa) 19.4
Isoelectric Point (pI) 4.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 1
Outer Membrane Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7JRK MEMBRANE PROTEIN 08/12/20 The Structure of BamE from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.71 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 140 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004409 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4765
Search term: omlA

Human Homologs

References

Pseudomonas aeruginosa fur overlaps with a gene encoding a novel outer membrane lipoprotein, OmlA.
Ochsner UA, Vasil AI, Johnson Z, Vasil ML
J Bacteriol 1999 Feb;181(4):1099-109
PubMed ID: 9973334
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344