Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4776
|
Name |
pmrA
|
Replicon | chromosome |
Genomic location | 5364071 - 5364736 (+ strand) |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_253464.1 |
GI | 15599970 |
Affymetrix | PA4776_at |
Entrez | 881834 |
GenBank | AAG08162.1 |
INSDC | AAG08162.1 |
NCBI Locus Tag | PA4776 |
protein_id(GenBank) | gb|AAG08162.1|AE004891_4|gnl|PseudoCAP|PA4776 |
TIGR | NTL03PA04777 |
UniParc | UPI00000C5DFC |
UniProtKB Acc | Q9HV32 |
UniProtKB ID | Q9HV32_PSEAE |
UniRef100 | UniRef100_Q9HV32 |
UniRef50 | UniRef50_I0HMN0 |
UniRef90 | UniRef90_Q9HV32 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
PmrA: two-component regulator system response regulator PmrA
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -4.56 |
Kyte-Doolittle Hydrophobicity Value | -0.154 |
Molecular Weight (kDa) | 24.4 |
Isoelectric Point (pI) | 5.63 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 612 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004418 (471 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4776
Search term: pmrA
|
Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa.
McPhee JB, Lewenza S, Hancock RE
Mol Microbiol 2003 Oct;50(1):205-17
PubMed ID: 14507375
|
PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A.
Moskowitz SM, Ernst RK, Miller SI
J Bacteriol 2004 Jan;186(2):575-9
PubMed ID: 14702327
|
PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.
Moskowitz SM, Brannon MK, Dasgupta N, Pier M, Sgambati N, Miller AK, Selgrade SE, Miller SI, Denton M, Conway SP, Johansen HK, Høiby N
Antimicrob Agents Chemother 2012 Feb;56(2):1019-30
PubMed ID: 22106224
|