Pseudomonas aeruginosa PAO1, PA4776 (pmrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4776
Name
pmrA
Replicon chromosome
Genomic location 5364071 - 5364736 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253464.1
GI 15599970
Affymetrix PA4776_at
Entrez 881834
GenBank AAG08162.1
INSDC AAG08162.1
NCBI Locus Tag PA4776
protein_id(GenBank) gb|AAG08162.1|AE004891_4|gnl|PseudoCAP|PA4776
TIGR NTL03PA04777
UniParc UPI00000C5DFC
UniProtKB Acc Q9HV32
UniProtKB ID Q9HV32_PSEAE
UniRef100 UniRef100_Q9HV32
UniRef50 UniRef50_I0HMN0
UniRef90 UniRef90_Q9HV32

Product

Feature Type CDS
Coding Frame 1
Product Name
PmrA: two-component regulator system response regulator PmrA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.56
Kyte-Doolittle Hydrophobicity Value -0.154
Molecular Weight (kDa) 24.4
Isoelectric Point (pI) 5.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 612 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004418 (471 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4776
Search term: pmrA

Human Homologs

References

Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa.
McPhee JB, Lewenza S, Hancock RE
Mol Microbiol 2003 Oct;50(1):205-17
PubMed ID: 14507375
PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A.
Moskowitz SM, Ernst RK, Miller SI
J Bacteriol 2004 Jan;186(2):575-9
PubMed ID: 14702327
PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.
Moskowitz SM, Brannon MK, Dasgupta N, Pier M, Sgambati N, Miller AK, Selgrade SE, Miller SI, Denton M, Conway SP, Johansen HK, Høiby N
Antimicrob Agents Chemother 2012 Feb;56(2):1019-30
PubMed ID: 22106224