Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4878
|
Name |
brlR
|
Replicon | chromosome |
Genomic location | 5473766 - 5474578 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_253565.1 |
GI | 15600071 |
Affymetrix | PA4878_at |
DNASU | PaCD00008112 |
Entrez | 882234 |
GenBank | AAG08263.1 |
INSDC | AAG08263.1 |
NCBI Locus Tag | PA4878 |
protein_id(GenBank) | gb|AAG08263.1|AE004901_5|gnl|PseudoCAP|PA4878 |
TIGR | NTL03PA04879 |
UniParc | UPI00000C5E54 |
UniProtKB Acc | Q9HUT5 |
UniProtKB ID | Q9HUT5_PSEAE |
UniRef100 | UniRef100_W0YYW8 |
UniRef50 | UniRef50_A6VCY6 |
UniRef90 | UniRef90_W0YYW8 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
BrlR
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -0.39 |
Kyte-Doolittle Hydrophobicity Value | -0.451 |
Molecular Weight (kDa) | 31.2 |
Isoelectric Point (pI) | 6.92 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
5XBW | DNA BINDING PROTEIN | 03/21/17 | The structure of BrlR | Pseudomonas aeruginosa PAO1 | 3.109 | X-RAY DIFFRACTION | 100.0 |
5XBT | DNA BINDING PROTEIN | 03/21/17 | The structure of BrlR bound to c-di-GMP | Pseudomonas aeruginosa PAO1 | 2.495 | X-RAY DIFFRACTION | 100.0 |
5YC9 | TRANSCRIPTION | 09/07/17 | Crystal structure of a Pseudomonas aeruginosa transcriptional regulator | Pseudomonas aeruginosa | 2.9 | X-RAY DIFFRACTION | 100.0 |
5XBI | TRANSCRIPTION | 03/17/17 | The structure of BrlR-C domain bound to 3-amino-2-phenazino(a pyocyanin analog) | Pseudomonas aeruginosa | 1.4 | X-RAY DIFFRACTION | 99.3 |
5XQL | TRANSCRIPTION | 06/07/17 | Crystal structure of a Pseudomonas aeruginosa transcriptional regulator | Pseudomonas aeruginosa | 2.494 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 235 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004506 (322 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4878
Search term: brlR
Search term: BrlR
|
The MerR-like transcriptional regulator BrlR contributes to Pseudomonas aeruginosa biofilm tolerance.
Liao J, Sauer K
J Bacteriol 2012 Sep;194(18):4823-36
PubMed ID: 22730129
|
The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms.
Liao J, Schurr MJ, Sauer K
J Bacteriol 2013 Aug;195(15):3352-63
PubMed ID: 23687276
|
The MerR-like regulator BrlR impairs Pseudomonas aeruginosa biofilm tolerance to colistin by repressing PhoPQ.
Chambers JR, Sauer K
J Bacteriol 2013 Oct;195(20):4678-88
PubMed ID: 23935054
|