Pseudomonas aeruginosa PAO1, PA4921 (choE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA4921
Name
choE
Replicon chromosome
Genomic location 5520672 - 5521595 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs
CommentGene changed names between the authors' original submission and the paper acceptance.

Cross-References

RefSeq NP_253608.1
GI 15600114
Affymetrix PA4921_at
Entrez 878045
GenBank AAG08306.1
INSDC AHL26984.1
NCBI Locus Tag PA4921
protein_id(GenBank) gb|AAG08306.1|AE004905_4|gnl|PseudoCAP|PA4921
TIGR NTL03PA04922
UniParc UPI00000C5E7D
UniProtKB Acc Q9HUP2
UniProtKB ID Q9HUP2_PSEAE
UniRef100 UniRef100_Q9HUP2
UniRef50 UniRef50_Q9HUP2
UniRef90 UniRef90_Q9HUP2

Product

Feature Type CDS
Coding Frame 1
Product Name
cholinesterase, ChoE
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.31
Kyte-Doolittle Hydrophobicity Value -0.227
Molecular Weight (kDa) 33.5
Isoelectric Point (pI) 8.46

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Unknown Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 72 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004538 (839 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4921
Search term: choE

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Molecular cloning of a phospholipid-cholesterol acyltransferase from Aeromonas hydrophila. Sequence homologies with lecithin-cholesterol acyltransferase and other lipases.
Thornton J, Howard SP, Buckley JT
Biochim. Biophys. Acta 1988 Mar;959(2):153-9
PubMed ID: 3280033
A Pseudomonas aeruginosa PAO1 acetylcholinesterase is encoded by the PA4921 gene and belongs to the SGNH hydrolase family.
Sánchez DG, Otero LH, Hernández CM, Serra AL, Encarnación S, Domenech CE, Lisa AT
Microbiol. Res. 2012 Jun;167(6):317-25
PubMed ID: 22192836