Pseudomonas aeruginosa PAO1, PA4977 (aruI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4977
Name
aruI
Synonym: aruI
Replicon chromosome
Genomic location 5587574 - 5589253 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253664.1
GI 15600170
Affymetrix PA4977_at
Entrez 880189
GenBank AAG08362.1
NCBI Locus Tag PA4977
protein_id(GenBank) gb|AAG08362.1|AE004910_9|gnl|PseudoCAP|PA4977
TIGR NTL03PA04978
UniProtKB Acc Q9HUI8
UniProtKB ID Q9HUI8_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
2-ketoarginine decarboxylase, AruI
Product Name Confidence: Class 1
Synonyms 2-ketoarginine decarboxylase, AruI
Evidence for Translation
Charge (pH 7) 1.48
Kyte-Doolittle Hydrophobicity Value 0.069
Molecular Weight (kDa) 59.4
Isoelectric Point (pI) 7.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 594 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004591 (364 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4977
Search term: aruI

Human Homologs

Ensembl 110, assembly GRCh38.p14
2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856]
E-value: 1.9e-20
Percent Identity: 23.3

References

Characterization of an arginine:pyruvate transaminase in arginine catabolism of Pseudomonas aeruginosa PAO1.
Yang Z, Lu CD
J Bacteriol 2007 Jun;189(11):3954-9
PubMed ID: 17416668
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
Yang Z, Lu CD
J Bacteriol 2007 Jun;189(11):3945-53
PubMed ID: 17416670