Pseudomonas aeruginosa PAO1, PA5170 (arcD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5170
Name
arcD
Replicon chromosome
Genomic location 5820910 - 5822358 (+ strand)
Transposon Mutants 11 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253857.1
GI 15600363
Affymetrix PA5170_arcD_at
Entrez 881800
GenBank AAG08555.1
INSDC AAG08555.1
NCBI Locus Tag PA5170
protein_id(GenBank) gb|AAG08555.1|AE004930_1|gnl|PseudoCAP|PA5170
TIGR NTL03PA05171
UniParc UPI00000618AA
UniProtKB Acc P18275
UniProtKB ID ARCD_PSEAE
UniRef100 UniRef100_P18275
UniRef50 UniRef50_P18275
UniRef90 UniRef90_P18275

Product

Feature Type CDS
Coding Frame 1
Product Name
arginine/ornithine antiporter
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.07
Kyte-Doolittle Hydrophobicity Value 0.847
Molecular Weight (kDa) 52.0
Isoelectric Point (pI) 7.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 270 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004758 (484 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5170
Search term: arcD

Human Homologs

References

Characterization of the arcD arginine:ornithine exchanger of Pseudomonas aeruginosa. Localization in the cytoplasmic membrane and a topological model.
Bourdineaud JP, Heierli D, Gamper M, Verhoogt HJ, Driessen AJ, Konings WN, Lazdunski C, Haas D
J Biol Chem 1993 Mar 15;268(8):5417-24
PubMed ID: 8449902
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
arcD, the first gene of the arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa, encodes an arginine-ornithine exchanger.
Verhoogt HJ, Smit H, Abee T, Gamper M, Driessen AJ, Haas D, Konings WN
J Bacteriol 1992 Mar;174(5):1568-73
PubMed ID: 1311296