Pseudomonas aeruginosa PAO1, PA5231

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5231
Name
Synonym: yhiH
Replicon chromosome
Genomic location 5887082 - 5889832 (- strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253918.1
GI 15600424
Affymetrix PA5231_at
Entrez 880797
GenBank AAG08616.1
INSDC AAG08616.1
NCBI Locus Tag PA5231
protein_id(GenBank) gb|AAG08616.1|AE004935_13|gnl|PseudoCAP|PA5231
TIGR NTL03PA05232
UniParc UPI00000C5F68
UniProtKB Acc Q9HTV9
UniProtKB ID Q9HTV9_PSEAE
UniRef100 UniRef100_X6Y9K3
UniRef50 UniRef50_A0A085J099
UniRef90 UniRef90_A6VE05

Product

Feature Type CDS
Coding Frame 1
Product Name
probable ATP-binding/permease fusion ABC transporter
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.58
Kyte-Doolittle Hydrophobicity Value 0.101
Molecular Weight (kDa) 99.9
Isoelectric Point (pI) 6.58

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004812 (459 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5231

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33]
E-value: 2.3e-31
Percent Identity: 34.3
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33]
E-value: 2.3e-31
Percent Identity: 34.3

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295