Pseudomonas aeruginosa PAO1, PA5294

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5294
Name
Replicon chromosome
Genomic location 5959474 - 5960940 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253981.1
GI 15600487
Affymetrix PA5294_at
Entrez 880556
GenBank AAG08679.1
INSDC AAG08679.1
NCBI Locus Tag PA5294
protein_id(GenBank) gb|AAG08679.1|AE004942_2|gnl|PseudoCAP|PA5294
TIGR NTL03PA05295
UniParc UPI0000130363
UniProtKB Acc Q9HTR0
UniProtKB ID NORM_PSEAE
UniRef100 UniRef100_Q9HTR0
UniRef50 UniRef50_Q9HTR0
UniRef90 UniRef90_Q9HTR0

Product

Feature Type CDS
Coding Frame 1
Product Name
putative multidrug efflux pump
Product Name Confidence: Class 3
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 6.88
Kyte-Doolittle Hydrophobicity Value 0.826
Molecular Weight (kDa) 50.6
Isoelectric Point (pI) 8.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 445 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001295 (965 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5294

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa.
He GX, Kuroda T, Mima T, Morita Y, Mizushima T, Tsuchiya T
J Bacteriol 2004 Jan;186(1):262-5
PubMed ID: 14679249