Pseudomonas aeruginosa PAO1, PA5313 (gabT2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5313
Name
gabT2
Synonym: paaT
Replicon chromosome
Genomic location 5983820 - 5985154 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_254000.1
GI 15600506
Affymetrix PA5313_at
Entrez 877980
GenBank AAG08698.1
INSDC AAG08698.1
NCBI Locus Tag PA5313
protein_id(GenBank) gb|AAG08698.1|AE004944_2|gnl|PseudoCAP|PA5313
TIGR NTL03PA05314
UniParc UPI00000C5FA0
UniProtKB Acc Q9HTP1
UniProtKB ID Q9HTP1_PSEAE
UniRef100 UniRef100_Q9HTP1
UniRef50 UniRef50_Q9I700
UniRef90 UniRef90_A0A069Q0P3

Product

Feature Type CDS
Coding Frame 1
Product Name
Transaminase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.53
Kyte-Doolittle Hydrophobicity Value -0.013
Molecular Weight (kDa) 48.3
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 639 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000130 (850 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5313
Search term: gabT2
Search term: Transaminase

Human Homologs

Ensembl 110, assembly GRCh38.p14
ornithine aminotransferase [Source:HGNC Symbol;Acc:HGNC:8091]
E-value: 1.3e-32
Percent Identity: 27.3

References

Crystal structure analysis of omega-amino acid:pyruvate aminotransferase with a newly developed Weissenberg camera and an imaging plate using synchrotron radiation.
Watanabe N, Sakabe K, Sakabe N, Higashi T, Sasaki K, Aibara S, Morita Y, Yonaha K, Toyama S, Fukutani H
J Biochem 1989 Jan;105(1):1-3
PubMed ID: 2500426
Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1.
Yao X, He W, Lu CD
J. Bacteriol. 2011 Aug;193(15):3923-30
PubMed ID: 21622750