Pseudomonas aeruginosa PAO1, PA5375 (betT1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5375
Name
betT1
Replicon chromosome
Genomic location 6051644 - 6053194 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentHigh affinity choline-specific importer functions at low osmolarity
CommentHigh affinity choline-specific importer functions at low osmolarity

Cross-References

RefSeq NP_254062.1
GI 15600568
Affymetrix PA5375_betT1_at
Entrez 880283
GenBank AAG08760.1
INSDC AAG08760.1
NCBI Locus Tag PA5375
protein_id(GenBank) gb|AAG08760.1|AE004950_3|gnl|PseudoCAP|PA5375
TIGR NTL03PA05376
UniParc UPI00000C5FCC
UniProtKB Acc Q9HTI9
UniProtKB ID Q9HTI9_PSEAE
UniRef100 UniRef100_Q9HTI9
UniRef50 UniRef50_Q9HTI9
UniRef90 UniRef90_Q9HTI9

Product

Feature Type CDS
Coding Frame 1
Product Name
BetT1
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -1.22
Kyte-Doolittle Hydrophobicity Value 0.639
Molecular Weight (kDa) 56.1
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 255 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004939 (450 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5375
Search term: betT1
Search term: BetT1

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Three transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD.
Kappes RM, Kempf B, Bremer E
J Bacteriol 1996 Sep;178(17):5071-9
PubMed ID: 8752321
Roles of three transporters, CbcXWV, BetT1, and BetT3, in Pseudomonas aeruginosa choline uptake for catabolism.
Malek AA, Chen C, Wargo MJ, Beattie GA, Hogan DA
J Bacteriol 2011 Jun;193(12):3033-41
PubMed ID: 21478341