Pseudomonas aeruginosa PAO1, PA5470

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5470
Name
Synonym: prfH
Replicon chromosome
Genomic location 6158949 - 6159563 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254157.1
GI 15600663
Affymetrix PA5470_at
Entrez 877631
GenBank AAG08855.1
INSDC AAG08855.1
NCBI Locus Tag PA5470
protein_id(GenBank) gb|AAG08855.1|AE004959_11|gnl|PseudoCAP|PA5470
TIGR NTL03PA05471
UniParc UPI00000C6023
UniProtKB Acc Q9HTA0
UniProtKB ID Q9HTA0_PSEAE
UniRef100 UniRef100_U8LXJ1
UniRef50 UniRef50_P28369
UniRef90 UniRef90_W0YZQ0

Product

Feature Type CDS
Coding Frame 1
Product Name
probable peptide chain release factor
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) 12.05
Kyte-Doolittle Hydrophobicity Value -0.245
Molecular Weight (kDa) 22.3
Isoelectric Point (pI) 11.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 576 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005012 (312 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5470

Human Homologs

Ensembl 110, assembly GRCh38.p14
mitochondrial translation release factor 1 like [Source:HGNC Symbol;Acc:HGNC:21051]
E-value: 1.1e-08
Percent Identity: 51.7
Ensembl 110, assembly GRCh38.p14
mitochondrial translation release factor 1 like [Source:HGNC Symbol;Acc:HGNC:21051]
E-value: 1.1e-08
Percent Identity: 51.7
Ensembl 110, assembly GRCh38.p14
mitochondrial translation release factor 1 [Source:HGNC Symbol;Acc:HGNC:7469]
E-value: 1.1e-08
Percent Identity: 47.5
Ensembl 110, assembly GRCh38.p14
mitochondrial translation release factor 1 [Source:HGNC Symbol;Acc:HGNC:7469]
E-value: 1.1e-08
Percent Identity: 47.5

References

Sequence comparison of new prokaryotic and mitochondrial members of the polypeptide chain release factor family predicts a five-domain model for release factor structure.
Pel HJ, Rep M, Grivell LA
Nucleic Acids Res 1992 Sep 11;20(17):4423-8
PubMed ID: 1408743
Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product.
Morita Y, Sobel ML, Poole K
J Bacteriol 2006 Mar;188(5):1847-55
PubMed ID: 16484195