Pseudomonas aeruginosa PAO1, PA2559.1 (srfA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
| Locus Tag |
PA2559.1
|
| NCBI Locus Tag | PA2559a |
| Name |
srfA
|
| Replicon | chromosome |
| Genomic location | 2894147 - 2894377 (+ strand) |
| Comment | Named derived from “stress response facilitator” |
| Comment | SrfA interacts with PA2559 and PA2560 |
| Comment | Loss of SrfA abolishes biofilm formation |
Cross-References
| RefSeq | YP_008719755.1 |
| GI | |
| Entrez | 17373363 |
| NCBI Locus Tag | PA2559a |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
SrfA
|
| Evidence for Translation | |
| Charge (pH 7) | -2.01 |
| Kyte-Doolittle Hydrophobicity Value | -1.534 |
| Molecular Weight (kDa) | 9.1 |
| Isoelectric Point (pI) | 4.83 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 7XNJ | GENE REGULATION | 04/28/22 | Stress Response Facilitator A SrfA | Pseudomonas aeruginosa PAO1 | 2.1 | X-RAY DIFFRACTION | 98.7 |
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG008401 (1 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA2559.1
Search term: srfA
Search term: SrfA
|
Human Homologs
References
|
Cell wall stress activates expression of a novel stress response facilitator (SrfA) under σ22 (AlgT/U) control in Pseudomonas aeruginosa.
Wood LF, Ohman DE
Microbiology (Reading, Engl.) 2015 Jan;161(Pt 1):30-40
PubMed ID: 25336469
|