Pseudomonas aeruginosa UCBPP-PA14, PA14_00200 (def)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_00200
Name
def
Replicon chromosome
Genomic location 21088 - 21594 (- strand)

Cross-References

RefSeq YP_788174.1
GI 116053739
EC Number 3.5.1.88
Entrez 4385200
INSDC ABJ14975.1
NCBI Locus Tag PA14_00200
UniParc UPI00003E3192
UniProtKB Acc Q02V62
UniProtKB ID Q02V62_PSEAB
UniRef100 UniRef100_Q02V62
UniRef50 UniRef50_Q9I7A8
UniRef90 UniRef90_Q9I7A8

Product

Feature Type CDS
Coding Frame 1
Product Name
peptide deformylase
Synonyms
Evidence for Translation
Charge (pH 7) -8.13
Kyte-Doolittle Hydrophobicity Value -0.441
Molecular Weight (kDa) 19.4
Isoelectric Point (pI) 4.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1S17 HYDROLASE 01/05/04 Identification of Novel Potent Bicyclic Peptide Deformylase Inhibitors PSEUDOMONAS AERUGINOSA 1.95 X-RAY DIFFRACTION 100.0
1N5N HYDROLASE 11/06/02 Crystal Structure of Peptide Deformylase from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 100.0
1LRY HYDROLASE 05/16/02 Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin PSEUDOMONAS AERUGINOSA 2.6 X-RAY DIFFRACTION 99.4
1IX1 HYDROLASE 06/07/02 Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin PSEUDOMONAS AERUGINOSA 1.85 X-RAY DIFFRACTION 99.4

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide DB04310 DrugBank 5.0.6 Q9I7A8 Peptide deformylase 99.4 168 2.0e-91
2-(3,4-Dihydro-3-Oxo-2h-Benzo[B][1,4]Thiazin-2-Yl)-N-Hydroxyacetamide DB02036 DrugBank 5.0.6 Q9I7A8 Peptide deformylase 99.4 168 2.0e-91
N-(2-Acetamido)Iminodiacetic Acid DB02810 DrugBank 5.0.6 Q9I7A8 Peptide deformylase 99.4 168 2.0e-91

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 586 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000019 (562 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_00200
Search term: def

Human Homologs

Ensembl 86, assembly GRCh38.p7
peptide deformylase (mitochondrial) [Source:HGNC Symbol;Acc:HGNC:30012]
E-value: 3.8e-15
Percent Identity: 32.7

References

No references are associated with this feature.