Pseudomonas aeruginosa UCBPP-PA14, PA14_15260

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_15260
Name
Replicon	chromosome
Genomic location	1293079 - 1294221 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_789359.1
GI	116051799
Entrez	4381863
INSDC	ABJ13035.1
NCBI Locus Tag	PA14_15260
UniParc	UPI00003961A2
UniProtKB Acc	Q02RS7
UniProtKB ID	Q02RS7_PSEAB
UniRef100	UniRef100_S0HT77
UniRef50	UniRef50_S0ACH9
UniRef90	UniRef90_V6AAR1

Product

Feature Type	CDS
Coding Frame	1
Product Name	acetylpolyamine aminohydrolase
Synonyms
Evidence for Translation
Charge (pH 7)	-6.57
Kyte-Doolittle Hydrophobicity Value	-0.115
Molecular Weight (kDa)	41.1
Isoelectric Point (pI)	6.23

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5G11	HYDROLASE	03/23/16	Pseudomonas aeruginosa HDAH bound to PFSAHA.	PSEUDOMONAS AERUGINOSA	2.48	X-RAY DIFFRACTION	99.2
5G0X	HYDROLASE	03/23/16	Pseudomonas aeruginosa HDAH bound to acetate.	PSEUDOMONAS AERUGINOSA	1.7	X-RAY DIFFRACTION	99.5
5LI3	SIGNALING PROTEIN	07/14/16	Crystal structure of HDAC-like protein from P. aeruginosa in complex with a photo-switchable inhibitor.	Pseudomonas aeruginosa	2.4	X-RAY DIFFRACTION	99.5
5G10	HYDROLASE	03/23/16	Pseudomonas aeruginosa HDAH bound to 9,9,9 trifluoro-8,8-dihydroy-N-phenylnonanamide	PSEUDOMONAS AERUGINOSA	1.71	X-RAY DIFFRACTION	99.5
5G0Y	HYDROLASE	03/23/16	Pseudomonas aeruginosa HDAH unliganded.	PSEUDOMONAS AERUGINOSA	2.29	X-RAY DIFFRACTION	99.5
5G12	HYDROLASE	03/23/16	Pseudomonas aeruginosa HDAH (Y313F) unliganded.	PSEUDOMONAS AERUGINOSA	2.02	X-RAY DIFFRACTION	99.2
5G13	HYDROLASE	03/23/16	Pseudomonas aeruginosa HDAH (H143A) unliganded.	PSEUDOMONAS AERUGINOSA	1.99	X-RAY DIFFRACTION	99.2

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 443 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001890 (353 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_15260 Search term: acetylpolyamine aminohydrolase

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000216271 histone deacetylase 10 [Source:HGNC Symbol;Acc:HGNC:18128] E-value: 1.4e-38 Percent Identity: 36.6

References