Pseudomonas aeruginosa UCBPP-PA14, PA14_22760 (cpxR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_22760
Name
cpxR
Replicon chromosome
Genomic location 1978689 - 1979366 (- strand)

Cross-References

RefSeq YP_789975.1
GI 116051194
Entrez 4381198
INSDC ABJ12430.1
NCBI Locus Tag PA14_22760
UniParc UPI00000C594A
UniProtKB Acc Q02Q11
UniProtKB ID Q02Q11_PSEAB
UniRef100 UniRef100_W0YUZ4
UniRef50 UniRef50_Q4KGB4
UniRef90 UniRef90_M4WZL9

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -3.62
Kyte-Doolittle Hydrophobicity Value -0.280
Molecular Weight (kDa) 24.8
Isoelectric Point (pI) 5.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002411 (561 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_22760
Search term: cpxR

References

CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa.
Tian ZX, Yi XX, Cho A, O'Gara F, Wang YP
PLoS Pathog. 2016 Oct;12(10):e1005932
PubMed ID: 27736975