Pseudomonas aeruginosa UCBPP-PA14, PA14_38380

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_38380
Name
Replicon chromosome
Genomic location 3420889 - 3421521 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_791219.1
GI 116049970
Entrez 4380304
INSDC ABJ11206.1
NCBI Locus Tag PA14_38380
UniParc UPI0000152D22
UniProtKB Acc Q02LG7
UniProtKB ID Q02LG7_PSEAB
UniRef100 UniRef100_S0INT4
UniRef50 UniRef50_Q2SVT2
UniRef90 UniRef90_W0YRR0

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7) 1.06
Kyte-Doolittle Hydrophobicity Value -0.388
Molecular Weight (kDa) 23.7
Isoelectric Point (pI) 7.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexZ MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. [PMID:15336398] ARO:3003709 protein overexpression model Strict 414.8 99.05 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2WUI TRANSCRIPTION 10/05/09 Crystal Structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa. PSEUDOMONAS AERUGINOSA 2.9 X-RAY DIFFRACTION 99.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 247 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003420 (237 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_38380

Human Homologs

References

No references are associated with this feature.