Pseudomonas aeruginosa UCBPP-PA14, PA14_41130 (nppA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_41130
Name
nppA2
Replicon chromosome
Genomic location 3667060 - 3668907 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq YP_791433.1
GI 116049760
Entrez 4383092
INSDC ABJ10996.1
NCBI Locus Tag PA14_41130
UniParc UPI000045D1E9
UniProtKB Acc Q02KV3
UniProtKB ID Q02KV3_PSEAB
UniRef100 UniRef100_A0A080VL20
UniRef50 UniRef50_A0A0D0RCL5
UniRef90 UniRef90_A6V710

Product

Feature Type CDS
Coding Frame 1
Product Name
ABC transporter substrate-binding protein NppA2
Product Name Confidence: Class 1
Synonyms NppA2
ABC transporter substrate-binding protein
Evidence for Translation
Charge (pH 7) -2.87
Kyte-Doolittle Hydrophobicity Value -0.485
Molecular Weight (kDa) 70.4
Isoelectric Point (pI) 6.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 433 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003391 (817 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_41130
Search term: nppA2

Human Homologs

References

The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics.
Pletzer D, Braun Y, Dubiley S, Lafon C, Köhler T, Page MGP, Mourez M, Severinov K, Weingart H
J Bacteriol 2015 Jul;197(13):2217-2228
PubMed ID: 25917903
High-level pacidamycin resistance in Pseudomonas aeruginosa is mediated by an opp oligopeptide permease encoded by the opp-fabI operon.
Mistry A, Warren MS, Cusick JK, Karkhoff-Schweizer RR, Lomovskaya O, Schweizer HP
Antimicrob Agents Chemother 2013 Nov;57(11):5565-71
PubMed ID: 23979749