Pseudomonas aeruginosa UCBPP-PA14, PA14_41160 (nppD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_41160
Name
nppD
Replicon chromosome
Genomic location 3671022 - 3672632 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_791436.1
GI 116049757
Entrez 4383089
INSDC ABJ10993.1
NCBI Locus Tag PA14_41160
UniParc UPI000045D1E7
UniProtKB Acc Q02KV0
UniProtKB ID Q02KV0_PSEAB
UniRef100 UniRef100_S0IQB3
UniRef50 UniRef50_G8SAH9
UniRef90 UniRef90_B7VB70

Product

Feature Type CDS
Coding Frame 1
Product Name
peptidyl nucleoside antibiotic ABC transporter ATP-binding protein NppD
Product Name Confidence: Class 1
Synonyms NppD
ABC transporter ATP-binding protein
Evidence for Translation
Charge (pH 7) 2.99
Kyte-Doolittle Hydrophobicity Value -0.079
Molecular Weight (kDa) 59.0
Isoelectric Point (pI) 7.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003590 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_41160
Search term: nppD

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 6.4e-21
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 6.4e-21
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 6.4e-21
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 6.4e-21
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 6.4e-21
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 6.4e-21
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 6.4e-21
Percent Identity: 31.2

References

The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics.
Pletzer D, Braun Y, Dubiley S, Lafon C, Köhler T, Page MGP, Mourez M, Severinov K, Weingart H
J Bacteriol 2015 Jul;197(13):2217-2228
PubMed ID: 25917903
High-level pacidamycin resistance in Pseudomonas aeruginosa is mediated by an opp oligopeptide permease encoded by the opp-fabI operon.
Mistry A, Warren MS, Cusick JK, Karkhoff-Schweizer RR, Lomovskaya O, Schweizer HP
Antimicrob Agents Chemother 2013 Nov;57(11):5565-71
PubMed ID: 23979749