Pseudomonas aeruginosa UCBPP-PA14, PA14_42880 (stk1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_42880
Name
stk1
Replicon chromosome
Genomic location 3810500 - 3811489 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 12 transposon mutants in orthologs

Cross-References

RefSeq YP_791575.1
GI 116049620
Entrez 4382933
INSDC ABJ10856.1
NCBI Locus Tag PA14_42880
UniParc UPI00003967F3
UniProtKB Acc Q02KG1
UniProtKB ID Q02KG1_PSEAB
UniRef100 UniRef100_Q02KG1
UniRef50 UniRef50_Q9I354
UniRef90 UniRef90_Q9I354

Product

Feature Type CDS
Coding Frame 1
Product Name
Stk1
Product Name Confidence: Class 1
Synonyms serine-threonine kinase Stk1
Evidence for Translation
Charge (pH 7) -6.70
Kyte-Doolittle Hydrophobicity Value -0.072
Molecular Weight (kDa) 36.0
Isoelectric Point (pI) 5.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 19497948
Source 2
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse acute lung Infection model
Infection model Mouse burn Infection model
Reference 19497948

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 446 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000073 (1398 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_42880
Search term: stk1
Search term: Stk1

Human Homologs

Ensembl 94, assembly GRCh38.p12
serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209]
E-value: 2.7e-23
Percent Identity: 31.9

References

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis.
Lesic B, Starkey M, He J, Hazan R, Rahme LG
Microbiology (Reading, Engl.) 2009 Sep;155(Pt 9):2845-55
PubMed ID: 19497948
The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells.
Sana TG, Hachani A, Bucior I, Soscia C, Garvis S, Termine E, Engel J, Filloux A, Bleves S
J. Biol. Chem. 2012 Aug;287(32):27095-105
PubMed ID: 22665491