Pseudomonas aeruginosa UCBPP-PA14, PA14_42970 (sfa2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_42970
Name
sfa2
Replicon chromosome
Genomic location 3819909 - 3821420 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_791583.1
GI 116049612
Entrez 4382925
INSDC ABJ10848.1
NCBI Locus Tag PA14_42970
UniParc UPI000045D1AD
UniProtKB Acc Q02KF3
UniProtKB ID Q02KF3_PSEAB
UniRef100 UniRef100_A0A022P6F5
UniRef50 UniRef50_G8Q740
UniRef90 UniRef90_B7UV58

Product

Feature Type CDS
Coding Frame 1
Product Name
Sfa2
Product Name Confidence: Class 1
Synonyms transcriptional regulator
Evidence for Translation
Charge (pH 7) -6.42
Kyte-Doolittle Hydrophobicity Value -0.039
Molecular Weight (kDa) 55.2
Isoelectric Point (pI) 6.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse acute lung Infection model
Infection model Mouse burn Infection model
Reference 19497948
Source 2
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 19497948

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 458 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003720 (433 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_42970
Search term: sfa2
Search term: Sfa2

Human Homologs

References

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis.
Lesic B, Starkey M, He J, Hazan R, Rahme LG
Microbiology (Reading) 2009 Sep;155(Pt 9):2845-2855
PubMed ID: 19497948
The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells.
Sana TG, Hachani A, Bucior I, Soscia C, Garvis S, Termine E, Engel J, Filloux A, Bleves S
J Biol Chem 2012 Aug 3;287(32):27095-105
PubMed ID: 22665491