Pseudomonas aeruginosa UCBPP-PA14, PA14_58375 (mdpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_58375
Name
mdpA
Replicon chromosome
Genomic location 5198442 - 5199659 (- strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_792843.1
GI 116054453
Entrez 4384142
INSDC ABJ15689.1
NCBI Locus Tag PA14_58375
UniParc UPI0000E44BE6
UniProtKB Acc Q02GU3
UniProtKB ID Q02GU3_PSEAB
UniRef100 UniRef100_A0A077JQA2
UniRef50 UniRef50_Q485R4
UniRef90 UniRef90_B7V038

Product

Feature Type CDS
Coding Frame 1
Product Name
metallopeptidase MdpA
Product Name Confidence: Class 2
Synonyms metallopeptidase
Evidence for Translation
Charge (pH 7) -8.80
Kyte-Doolittle Hydrophobicity Value -0.184
Molecular Weight (kDa) 44.1
Isoelectric Point (pI) 5.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 664 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004086 (318 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_58375
Search term: mdpA

Human Homologs

Ensembl 110, assembly GRCh38.p14
X-prolyl aminopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:28052]
E-value: 4.4e-14
Percent Identity: 29.8

References

Genetic analysis of genes involved in dipeptide metabolism and cytotoxicity in Pseudomonas aeruginosa PAO1.
Kiely PD, O'Callaghan J, Abbas A, O'Gara F
Microbiology (Reading) 2008 Aug;154(Pt 8):2209-2218
PubMed ID: 18667554