Pseudomonas aeruginosa UCBPP-PA14, PA14_61680 (prmC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_61680
Name
prmC
Replicon chromosome
Genomic location 5503596 - 5504426 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14

Cross-References

RefSeq YP_793126.1
GI 116052809
Entrez 4385642
INSDC ABJ14045.1
NCBI Locus Tag PA14_61680
UniParc UPI00000C5DB7
UniProtKB Acc Q02G10
UniProtKB ID Q02G10_PSEAB
UniRef100 UniRef100_Q9HVC8
UniRef50 UniRef50_Q9HVC8
UniRef90 UniRef90_Q9HVC8

Product

Feature Type CDS
Coding Frame 1
Product Name
S-adenosylmethionine-dependent methyltransferase, PrmC
Product Name Confidence: Class 1
Synonyms methyl transferase
Evidence for Translation
Charge (pH 7) -7.37
Kyte-Doolittle Hydrophobicity Value -0.168
Molecular Weight (kDa) 30.5
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Caenorhabditis elegans
Notes
Infection model C. elegans slow killing assay.
Reference 22911607

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 609 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004314 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_61680
Search term: prmC

Human Homologs

References

The peptide chain release factor methyltransferase PrmC is essential for pathogenicity and environmental adaptation of Pseudomonas aeruginosa PA14.
Pustelny C, Brouwer S, Müsken M, Bielecka A, Dötsch A, Nimtz M, Häussler S
Environ Microbiol 2013 Feb;15(2):597-609
PubMed ID: 23278968