Pseudomonas aeruginosa UCBPP-PA14, PA14_67560 (typA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_67560
Name
typA
Replicon chromosome
Genomic location 6034912 - 6036729 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_793587.1
GI 116053264
Entrez 4383429
INSDC ABJ14500.1
NCBI Locus Tag PA14_67560
UniParc UPI00000C5F0E
UniProtKB Acc Q02EP9
UniProtKB ID Q02EP9_PSEAB
UniRef100 UniRef100_Q9HU67
UniRef50 UniRef50_P0A3B2
UniRef90 UniRef90_Q9HU67

Product

Feature Type CDS
Coding Frame 1
Product Name
TypA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -16.36
Kyte-Doolittle Hydrophobicity Value -0.313
Molecular Weight (kDa) 66.9
Isoelectric Point (pI) 5.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004710 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_67560
Search term: typA
Search term: TypA

Human Homologs

Ensembl 110, assembly GRCh38.p14
GTP binding elongation factor GUF1 [Source:HGNC Symbol;Acc:HGNC:25799]
E-value: 1.4e-40
Percent Identity: 28.2

References

TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aeruginosa.
Neidig A, Yeung AT, Rosay T, Tettmann B, Strempel N, Rueger M, Lesouhaitier O, Overhage J
BMC Microbiol 2013 Apr 9;13:77
PubMed ID: 23570569
Identification of genes involved in swarming motility using a Pseudomonas aeruginosa PAO1 mini-Tn5-lux mutant library.
Overhage J, Lewenza S, Marr AK, Hancock RE
J Bacteriol 2007 Mar;189(5):2164-9
PubMed ID: 17158671
Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR.
Yeung AT, Torfs EC, Jamshidi F, Bains M, Wiegand I, Hancock RE, Overhage J
J Bacteriol 2009 Sep;191(18):5592-602
PubMed ID: 19592586