Pseudomonas aeruginosa UCBPP-PA14, PA14_70300 (sphA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_70300
Name
sphA
Replicon chromosome
Genomic location 6268955 - 6269905 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 6 transposon mutants in orthologs

Cross-References

RefSeq YP_793799.1
GI 116053472
Entrez 4385088
INSDC ABJ14708.1
NCBI Locus Tag PA14_70300
UniParc UPI0000397091
UniProtKB Acc Q02E37
UniProtKB ID Q02E37_PSEAB
UniRef100 UniRef100_S0HIE1
UniRef50 UniRef50_Q1I8G0
UniRef90 UniRef90_A6VED2

Product

Feature Type CDS
Coding Frame 1
Product Name
SphA
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -7.41
Kyte-Doolittle Hydrophobicity Value -0.289
Molecular Weight (kDa) 35.6
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Outer Membrane Class 2
sequence alignment evidence used in manual assertion
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 60 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003078 (1032 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_70300
Search term: sphA
Search term: SphA

Human Homologs

References

Crystal structure of a COG4313 outer membrane channel.
van den Berg B, Bhamidimarri SP, Winterhalter M
Sci Rep 2015 Jul 7;5:11927
PubMed ID: 26149193
Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung.
LaBauve AE, Wargo MJ
PLoS Pathog 2014 Jan;10(1):e1003889
PubMed ID: 24465209