Pseudomonas aeruginosa UCBPP-PA14, PA14_70310 (sphD)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_70310
Name	sphD
Replicon	chromosome
Genomic location	6269976 - 6271184 (- strand)
Transposon Mutants	3 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_793800.1
GI	116053473
Entrez	4385089
INSDC	ABJ14709.1
NCBI Locus Tag	PA14_70310
UniParc	UPI0000E44C7E
UniProtKB Acc	Q02E36
UniProtKB ID	Q02E36_PSEAB
UniRef100	UniRef100_S0HZY4
UniRef50	UniRef50_A6VED3
UniRef90	UniRef90_A6VED3

Product

Feature Type	CDS
Coding Frame	1
Product Name	SphD Product Name Confidence: Class 1
Synonyms	hypothetical protein
Evidence for Translation
Charge (pH 7)	3.86
Kyte-Doolittle Hydrophobicity Value	-0.137
Molecular Weight (kDa)	44.5
Isoelectric Point (pI)	8.41

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 30 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004895 (351 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_70310 Search term: sphD Search term: SphD

Human Homologs

References

Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung. LaBauve AE, Wargo MJ PLoS Pathog 2014 Jan;10(1):e1003889 PubMed ID: 24465209