Pseudomonas entomophila L48, PSEEN1550 (aprA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas entomophila L48
Locus Tag
PSEEN1550
Name
aprA
Replicon chromosome
Genomic location 1619738 - 1621195 (+ strand)

Cross-References

RefSeq YP_607222.1
GI 104780724
EC Number 3.4.24.40
Entrez 4086894
INSDC CAK14412.1
UniParc UPI0000D783FD
UniProtKB Acc Q1ID47
UniProtKB ID Q1ID47_PSEE4
UniRef100 UniRef100_Q1ID47
UniRef50 UniRef50_Q03023
UniRef90 UniRef90_Q1ID47

Product

Feature Type CDS
Coding Frame 1
Product Name
alkaline metalloprotease AprA
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -14.32
Kyte-Doolittle Hydrophobicity Value -0.246
Molecular Weight (kDa) 50930.4
Isoelectric Point (pI) 4.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Extracellular Class 1
sodium dodecyl sulfate polyacrylamide gel electrophoresis evidence
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Drosophila melanogaster
Notes aprA mutant exhibits attenuated virulence in Drosophila model of infection. AprA confers protection against the Imd-dependent immune response.
Reference 16789834

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 132 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001201 (1342 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSEEN1550
Search term: aprA

References

Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model.
Liehl P(1), Blight M, Vodovar N, Boccard F, Lemaitre B.
PLoS Pathog. 2006 Jun;2(6):e56.
PubMed ID: 16789834