Pseudomonas aeruginosa LESB58, PALES_10931 (tpbA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_10931
|
| Name |
tpbA
|
| Replicon | chromosome |
| Genomic location | 1184808 - 1185464 (- strand) |
Cross-References
| RefSeq | |
| GI | 218889835 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
protein tyrosine phosphatase TpbA
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 0.59 |
| Kyte-Doolittle Hydrophobicity Value | -0.123 |
| Molecular Weight (kDa) | 24004.3 |
| Isoelectric Point (pI) | 7.20 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2M3V | HYDROLASE | 01/26/13 | Solution structure of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonas aeruginosa | Pseudomonas aeruginosa | NOT | SOLUTION NMR | 96.9 |
| 4R0T | HYDROLASE | 08/01/14 | Crystal structure of P. aeruginosa TpbA (C132S) in complex with pTyr | Pseudomonas aeruginosa PAO1 | 2.603 | X-RAY DIFFRACTION | 99.1 |
| 4R0S | HYDROLASE | 08/01/14 | Crystal structure of P. aeruginosa TpbA | Pseudomonas aeruginosa PAO1 | 2.03 | X-RAY DIFFRACTION | 99.5 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 32 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001786 (406 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_10931
Search term: tpbA
Search term: protein tyrosine phosphatase TpbA
|
Human Homologs
References
|
Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).
Ueda A, Wood TK
PLoS Pathog 2009 Jun;5(6):e1000483
PubMed ID: 19543378
|